منابع مشابه
Translation Initiation System
AhtractRedundancy occurs naturally within RNA and DNA sequences [l]. The existence of tandem repeats, and sequences such as the Shine-Dalgarno sequence, the Pribnow box and the TATA box, leads us to believe that cellular communication systems use some method of coding to recognize valid information regions within a nucleotide sequence and correct for “transmission” errors such as mutations. In ...
متن کاملModifications on Translation Initiation
Two studies by Meyer et al. and Wang et al. demonstrate a role for m(6)A modification of mRNA in stimulating translation initiation. These findings add to the growing number of diverse mechanisms for translation initiation in eukaryotes.
متن کاملlacZ translation initiation mutations.
Sixteen single point mutations near the beginning of the lacZ gene have been isolated and their effect on lacZ expression has been measured. Five mutations were obtained that alter a potential stem-and-loop structure in the messenger RNA that masks the initiation codons. Formation of this stem-and-loop is a result of transcription of DNA sequences introduced during the cloning of the lac regula...
متن کاملMolecular Evolution Directs Protein Translation Using Unnatural Amino Acids.
Unnatural amino acids have in recent years established their importance in a wide range of fields, from pharmaceuticals to polymer science. Unnatural amino acids can increase the number of chemical groups within proteins and thus expand or enhance biological function. Our ability to utilize these important building blocks, however, has been limited by the inherent difficulty in incorporating th...
متن کاملSynaptic plasticity and translation initiation.
It is widely accepted that protein synthesis, including local protein synthesis at synapses, is required for several forms of synaptic plasticity. Local protein synthesis enables synapses to control synaptic strength independent of the cell body via rapid protein production from pre-existing mRNA. Therefore, regulation of translation initiation is likely to be intimately involved in modulating ...
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ژورنال
عنوان ژورنال: ACS Chemical Biology
سال: 2008
ISSN: 1554-8929,1554-8937
DOI: 10.1021/cb8000233